[Visual event-related potentials and reaction time in Parkinson's disease]. 1995

K Aragane, and H Tachibana, and M Sugita
Fifth Department of Internal Medicine, Hyogo College of Medicine.

Visual event-related potentials (ERPs) and reaction times in 29 patients with nondemented Parkinson's disease and 19 age-equivalent normal control subjects were measured during the physical and semantic discrimination tasks. The components of the NA, N2 and P3 and simple and choice reaction times were observed in both kinds of discrimination tasks. There were no significant differences in either the latency or amplitude of the ERP components (NA, N2 and P3) between the Parkinson's disease patients and normal subjects during the physical discrimination tasks, but the patients had significantly prolonged choice reaction time compared with the normal controls. During the semantic discrimination tasks, the N2 and P3 latencies and choice reaction time in patients with Parkinson's disease were significantly longer than those of the normal controls, although there were no differences in NA latency between the two groups. There were no significant differences in any of the amplitudes between these groups. These results suggest that motor preparation is delayed in patients with nondemented Parkinson's disease, although the stimulus evaluation process is largely preserved during the physical discrimination tasks. The results obtained from the semantic discrimination tasks are interpreted as electrophysiological signs of disturbance in stimulus classification and attention process in Parkinson's disease. From the automatic/controlled processes, the present results suggest that the automatic processing stage associated with NA may be less impaired than the attention-controlled processing reflected by N2 in patients with Parkinson's disease.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010300 Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D005074 Evoked Potentials, Visual The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways. Visual Evoked Response,Evoked Potential, Visual,Evoked Response, Visual,Evoked Responses, Visual,Potential, Visual Evoked,Potentials, Visual Evoked,Response, Visual Evoked,Responses, Visual Evoked,Visual Evoked Potential,Visual Evoked Potentials,Visual Evoked Responses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old

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