A REG study of 90 patients with migraine headaches demonstrated that a significant role in their genesis is played by regional hypertonia of cerebral vessels and phenomena of cerebral angiodystonia with a tendency towards spastic reactions rather than hypotonic. The use of stugeron for preventive treatment of migrain cephalgia was effective in 85 of the 100 treated patients and especially in those cases where there was an increased tone of the cerebral vessels according to the REG data. The most constant changes demonstrated by the REG were normalization of the vascular tone, more expressed in initial hypertone and to a less extent its influence on the cerebral blood flux (more frequently towards its increase and a decrease of hemispheric asymmetry). The authors consider it expedient to use REG methods when prescribing stugeron.