BIOMAT Database Logo BIOMAT Database Logo

Effect of roxithromycin on peripheral neutrophil adhesion molecules in patients with chronic lower respiratory tract disease. 1995

S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Second Department of Internal Medicine Nagasaki University School of Medicine, Japan.

To evaluate the effects of roxithromycin in patients with chronic lower respiratory tract disease including diffuse panbronchiolitis, we studied lymphocyte function-associated antigen-1 (LFA-1) and Mac-1, neutrophil adhesion molecules, using peripheral neutrophils from healthy volunteers and from patients with chronic lower respiratory tract disease. The number of Mac-1 expressed on neutrophils of the patients was significantly greater (0.68 +/- 0.16) than in the healthy subjects (0.45 +/- 0.14), while the number of LFA-1 expressed on neutrophils of the patients was nearly similar to that in the healthy volunteers (0.95 +/- 0.10 vs 0.89 +/- 0.11). The neutrophil numbers in bronchoalveolar lavage fluid and the number of Mac-1 expressed on peripheral neutrophils significantly decreased in all patients who responded clinically to a low dose of roxithromycin for a long period of time (56.0 +/- 25.2 vs. 22.7 +/- 19.7%, p < 0.05 and 0.70 +/- 0.16 vs. 0.59 +/- 0.08, p < 0.05, respectively), whereas roxithromycin had no effect on the quantitative expression of LFA-1 (0.96 +/- 0.14 to 1.00 +/- 0.09, not significant) in all responders.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D012140 Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM. Respiratory Diseases,Respiratory System Diseases,Disease, Respiratory System,Disease, Respiratory Tract,Respiratory System Disease,Respiratory Tract Disease
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial

Related Publications

S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
[Efficacy of roxithromycin in the treatment of lower respiratory tract infections in patients with chronic respiratory disease].
June 1991, Anales de medicina interna (Madrid, Spain : 1984),
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Roxithromycin and lower respiratory tract infections.
May 1994, The New Zealand medical journal,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Effect of transportation on lower respiratory tract contamination and peripheral blood neutrophil function.
June 1997, Australian veterinary journal,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Neutrophil adhesion molecules in chronic hemodialysis patients.
January 1994, Nephron,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
[Effect of smoking on chronic rhinosinusitis complicated with lower respiratory tract disease].
December 2018, Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
[Treatment of acute and bacterial lower respiratory tract infections with roxithromycin].
October 1992, La Tunisie medicale,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
[Effect of erythromycin on neutrophil adhesion molecules].
January 1993, Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Roxithromycin vs amoxycillin/clavulanic acid in lower respiratory tract infections.
August 1994, The New Zealand medical journal,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Economic analysis of treatment with roxithromycin in comparison with erythromycin in patients with lower respiratory tract infections.
January 1997, Scandinavian journal of infectious diseases,
S Kusano, and J Kadota, and S Kohno, and K Iida, and K Kawakami, and T Morikawa, and K Hara
Efficacy and tolerance of roxithromycin in comparison with erythromycin stearate in patients with lower respiratory tract infections.
January 1992, Scandinavian journal of infectious diseases,
Copied contents to your clipboard!