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The histochemical marker for nitric oxide synthase, NADPH diaphorase, is known to co-localize in mammalian neurones with various classical neurotransmitters and neuropeptides. The nervous system of the parasitic nematode Ascaris suum has previously been shown to contain both NADPH diaphorase activity and neuropeptide immunoreactivity. This study examined the possibility that NADPH diaphorase and neuropeptide immunoreactivity may co-exist in the same neurones. Two antisera were used, one raised to KYSALMFamide, a C-terminal synthetic analogue of SALMFamide 1 (GFNSALMFamide), and another that recognizes calcitonin-gene-related peptide (CGRP). We provide evidence that in a distinct subset of neurones in the ventral, dorsal and lateral ganglia NADPH diaphorase staining and SALMFamide-like immunoreactivity are co-localized, suggesting a possible role for nitric oxide in modulating neuropeptide activity in these regions. CGRP-like immunoreactivity was less widely distributed, and was not consistently co-localized with NADPH diaphorase.
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
January 1992,
Acta biologica Hungarica,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
June 1993,
Experimental parasitology,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
January 1990,
Comparative biochemistry and physiology. B, Comparative biochemistry,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
February 2001,
Parasitology,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
January 1994,
Parasitology,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
July 1991,
Biochemical and biophysical research communications,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
January 2022,
Frontiers in genetics,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
September 1991,
Molecular and biochemical parasitology,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
February 2004,
Protein expression and purification,
Z A Bascal, and
A Montgomery, and
L Holden-Dye, and
R G Williams, and
M C Thorndyke, and
R J Walker
August 1996,
Biochimica et biophysica acta,
