Biomaterial Database

Effects of in vivo vanadate administration on calcium exchange and contractile force of rat ventricular myocardium. 1996

B Pytkowski, and L Jagodzińska-Hamann

Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warsaw, Poland.

The aim of this study was to evaluate the effect of a 14-day intragastric administration of Na3VO4 (0.03 mmol/kg daily) on calcium metabolism and contractile force of rat myocardium. Left ventricular pressure as well as its first derivative (dP/dt) were registered with a balloon inserted to this ventricle and the cellular content of exchangeable calcium with the aid of 45Ca2+. Left ventricular pressure of the hearts exposed to vanadium was 11.8 +/- 0.2 kPa and was lower by 23% in comparison with control hearts (without vanadate), and its first derivative was 131.01 +/- 2.8 kPa/s (lower by 36.4%). The cellular content of exchangeable calcium in myocardium of rats treated with vanadium was 1.305 +/- 0.173 and 2.019 +/- 0.231 mmol/kg of wet weight (w.w.) in the stimulated and in the rested (for the last 10 min) ventricles, respectively. Accordingly, in the control group, the Ca content in stimulated hearts was lower by 0.384 mmol/kg w.w., and in the rested ones it was lower by 0.715. This indicates that the myocardial contractile force decreases, in spite of the fact that the content of calcium is considerably higher than that in the control group. These results also show a toxic effect of vanadate on the myocardium, probably due to large intracellular accumulation of calcium and cell damage.

UI	MeSH Term	Description	Entries
D007441	Intubation, Gastrointestinal	The insertion of a tube into the stomach, intestines, or other portion of the gastrointestinal tract to allow for the passage of food products, etc.	Intubation, Nasogastric,Gastrointestinal Intubation,Gastrointestinal Intubations,Intubations, Gastrointestinal,Intubations, Nasogastric,Nasogastric Intubation,Nasogastric Intubations
D008297	Male		Males
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006352	Heart Ventricles	The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.	Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014638	Vanadates	Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.	Decavanadate,Metavanadate,Orthovanadate,Oxyvanadium,Vanadyl,Monovanadate,Sodium Vanadate,Vanadate,Vanadate, Sodium