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The organization of rDNA-containing chromatin was analysed by transmission electron microscopy after treatment of cultured human lymphocytes with 5-azacytidine (ACR) or 5-azadeoxicytidine (AdCR). The number of observed acrocentric chromosomes with satellites was significantly increased after treatment with low doses of ACR or AdCR during the last 24 h of culture, whereas with exposures during the last 7 h the number remained normal. The results suggest that the incorporation of ACR and AdCR in the early period of the S-phase may have reverted the non-satellized to satellized chromosomes. The cytidine analogues may have become more visible during secondary constriction thus changing the NOR structure leading to an increased number of satellized chromosomes.
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1993,
Cytogenetics and cell genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
October 1979,
Human genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
December 1976,
Human genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1984,
Human genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
March 1994,
Experimental cell research,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1983,
Cytobios,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1981,
Human genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1981,
Human genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
July 1973,
Soviet genetics,
I Malheiro, and
B Porto, and
T Mello-Sampayo, and
V Goyanes
January 1971,
Cytogenetics,
