Biomaterial Database

Toxic effects of butylated hydroxytoluene on rats. 1977

J L Saheb, and S A Saheb

A study involving 96 weanling rats of both sexes was conducted to evaluate the effects of the antioxidant butylated hydroxytoluene on the plasma and liver lipid components. Comparative observations in the dietary content of butylated hydroxytoluene in ad libitum and underfed rats. A sex difference in the effects of butylated hydroxytoluene was noted. Butylated hydroxytoluene had a greater deleterious effect on the growth of the male than of the female rat, especially at the 0.5% dietary level (P less than 0.01). At this level, it also increased the relative weight of the liver (P less than 0.01) but had little effect on brain, heart and kidney in both sexes. The enlarged liver showed a marked elevation in the concentration of total lipids and of both total and esterified cholesterol. There were striking increases in the plasma total and esterified cholesterol and phospholipid levels in the butylated hydroxytoluene treated animals buy the triglycerides remained unaffected. The results obtained were more manifest in animals with restricted dietary intake. The changes observed in the lipid components occurred in parallel with the increasing amounts of the antioxidant in the diet. The effect of butylated hydroxytoluene on lipid metabolism is discussed.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D010743	Phospholipids	Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.	Phosphatides,Phospholipid
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002084	Butylated Hydroxytoluene	A di-tert-butyl PHENOL with antioxidant properties.	Butylhydroxytoluene,2,6-Bis(1,1-dimethylethyl)-4-methylphenol,2,6-Di-t-butyl-4-methylphenol,2,6-Di-tert-butyl-4-methylphenol,2,6-Di-tert-butyl-p-cresol,4-Methyl-2,6-ditertbutylphenol,BHT,Di-tert-butyl-methylphenol,Dibunol,Ionol,Ionol (BHT),2,6 Di t butyl 4 methylphenol,2,6 Di tert butyl 4 methylphenol,2,6 Di tert butyl p cresol,4 Methyl 2,6 ditertbutylphenol,Di tert butyl methylphenol,Hydroxytoluene, Butylated
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D003408	Cresols	Any of three isomeric crystalline aromatic methylphenols, also known as hydroxytoluenes.
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012737	Sex Factors	Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.	Factor, Sex,Factors, Sex,Sex Factor