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We have developed a host range system to measure the mutation frequency of feline immunodeficiency virus (FIV), the feline homologue of human immunodeficiency virus type 1 (HIV-1). When wild-type FIV was grown in the presence of a known mutagen, 5-bromo-2'-deoxyuridine (BUdR), a dose-dependent increase of host range mutants was detected. Using this system, we have evaluated the effects of antiviral drugs upon the mutation frequency of FIV. Subinhibitory concentrations of 3'-azido-3'-deoxythymidine (AZT), the most common antiviral drug used in AIDS chemotherapy, increased the mutation frequency of FIV in a dose-dependent manner. Two other antivirals, 2',3'-dideoxyinosine (ddI) and 2'3'-dideoxycytidine (ddC), did not show this effect.
R A LaCasse, and
K M Remington, and
T W North
January 1991,
Journal of virology,
R A LaCasse, and
K M Remington, and
T W North
September 1994,
Research in veterinary science,
R A LaCasse, and
K M Remington, and
T W North
June 1989,
Antimicrobial agents and chemotherapy,
R A LaCasse, and
K M Remington, and
T W North
October 1990,
AIDS research and human retroviruses,
R A LaCasse, and
K M Remington, and
T W North
March 1995,
Journal of virology,
R A LaCasse, and
K M Remington, and
T W North
January 1987,
Lancet (London, England),
R A LaCasse, and
K M Remington, and
T W North
February 1988,
Antimicrobial agents and chemotherapy,
R A LaCasse, and
K M Remington, and
T W North
October 1990,
Biochemical and biophysical research communications,
R A LaCasse, and
K M Remington, and
T W North
May 1989,
Antimicrobial agents and chemotherapy,
R A LaCasse, and
K M Remington, and
T W North
May 1995,
Veterinary immunology and immunopathology,
