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A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. 1996
K Savitsky, and
Y Ziv, and
A Bar-Shira, and
S Gilad, and
D A Tagle, and
S Smith, and
T Uziel, and
S Sfez, and
J Nahmias, and
A Sartiel, and
R L Eddy, and
T B Shows, and
F S Collins, and
Y Shiloh, and
G Rotman
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.
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