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1. The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories. 2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats. 3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). 4. Gluconeogenesis from lactate plus pyruvate was inhibited. 5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside. 6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria. 7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs.
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
March 1989,
Biochemical pharmacology,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 1996,
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 1987,
Cutis,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 1998,
Research communications in molecular pathology and pharmacology,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
July 2003,
The Journal of clinical psychiatry,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
September 1974,
European journal of biochemistry,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
July 2015,
Toxicology letters,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 1996,
Diseases of the colon and rectum,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 2018,
Biological & pharmaceutical bulletin,
C L Salgueiro-Pagadigorria, and
J Constantin, and
A Bracht, and
E A Nascimento, and
E L Ishii-Iwamoto
January 2005,
Digestive diseases and sciences,
