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The goal of AIDS Clinical Trials Group (ACTG) Protocol 229 was to evaluate the shorter term (24 week) and longer term (48 week) safety and activity of the HIV-1 proteinase inhibitor saquinavir in combination with zalcitabine (ddC) and zidovudine (ZDV) versus saquinavir in combination with ZDV versus ddC in combination with ZDV. This study confirms and extends the conclusions from the first 24 weeks of this study and showed that in subjects with extensive prior antiretroviral experience, the triple combination of saquinavir, ddC and ZDV was well-tolerated, safe and remained superior to the other double drug regimens as measured by CD4+ cell counts, quantitative HIV-1 microculture and plasma HIV-1 RNA levels.
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
August 1995,
Antiviral research,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
November 1997,
Antimicrobial agents and chemotherapy,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
February 1994,
Pediatrics,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
January 1995,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
June 1998,
AIDS (London, England),
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
November 2000,
AIDS (London, England),
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
June 2011,
Molecular pharmaceutics,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
January 2000,
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
June 1996,
The Journal of infectious diseases,
A C Collier, and
R W Coombs, and
D A Schoenfeld, and
R Bassett, and
A Baruch, and
L Corey
June 1999,
Clinical pharmacology and therapeutics,
