Biomaterial Database

Neurotrophins and nerve injury in the adult. 1996

V M Verge, and K A Gratto, and L A Karchewski, and P M Richardson

Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada.

A role for neurotrophins in mature primary sensory neurons persists, extending beyond that of promoting survival during development, to one of maintaining phenotypic and functional properties. Many adaptive changes that occur after peripheral axotomy and in axonal repair are believed to be influenced by altered availability of neurotrophic molecules to the neuron in this state. Indeed, administration of exogenous nerve growth factor counteracts many degenerative changes observed in the subpopulation of axotomized neurons which are nerve growth factor-responsive. Current efforts focus on defining actions of other neurotrophins (brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5) in nerve injury and repair, and the intracellular pathways involved. Knowledge gained from work focusing on nerve growth factor and neurotrophin-3 in supporting maintenance or modulation of aspects of the differentiated state of adult primary sensory neurons is discussed.

UI	MeSH Term	Description	Entries
D008959	Models, Neurological	Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.	Neurologic Models,Model, Neurological,Neurologic Model,Neurological Model,Neurological Models,Model, Neurologic,Models, Neurologic
D009414	Nerve Growth Factors	Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.	Neurite Outgrowth Factor,Neurite Outgrowth Factors,Neuronal Growth-Associated Protein,Neuronotrophic Factor,Neurotrophic Factor,Neurotrophic Factors,Neurotrophin,Neurotrophins,Growth-Associated Proteins, Neuronal,Neuronal Growth-Associated Proteins,Neuronotrophic Factors,Neurotrophic Protein,Neurotrophic Proteins,Proteins, Neuronal Growth-Associated,Factor, Neurite Outgrowth,Factor, Neuronotrophic,Factor, Neurotrophic,Factors, Nerve Growth,Factors, Neurite Outgrowth,Factors, Neuronotrophic,Factors, Neurotrophic,Growth Associated Proteins, Neuronal,Growth-Associated Protein, Neuronal,Neuronal Growth Associated Protein,Neuronal Growth Associated Proteins,Outgrowth Factor, Neurite,Outgrowth Factors, Neurite,Protein, Neuronal Growth-Associated
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D005727	Ganglia, Spinal	Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.	Dorsal Root Ganglia,Spinal Ganglia,Dorsal Root Ganglion,Ganglion, Spinal,Ganglia, Dorsal Root,Ganglion, Dorsal Root,Spinal Ganglion
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001369	Axons	Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.	Axon
D059348	Peripheral Nerve Injuries	Injuries to the PERIPHERAL NERVES.	Peripheral Nerve Injury,Nerve Injuries, Peripheral,Nerve Injury, Peripheral
D020933	Neurotrophin 3	A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.	Nerve Growth Factor 2