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The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined by double determinant immunoassay (DDIA), in 37 patients with atopic dermatitis (AD) and 31 age- and sex-matched healthy control subjects. Both sICAM-1 and sE-selectin levels were significantly higher in patients with AD than in healthy controls (P < 0.01), and were correlated with disease severity. A longitudinal study of patients with AD revealed that the levels of sICAM-1 decreased in those in whom symptoms improved. The sICAM-1 levels were significantly correlated with those of sE-selectin. Our studies suggest that such high levels of serum sICAM-1 and sE-selectin may affect the immune response in patients with AD. The levels of sICAM-1 and sE-selectin may be a useful immunological parameter for monitoring disease activity in AD.
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T Kageshita, and
T Kimura, and
M Tsujisaki, and
K Okajima, and
K Imai, and
T Ono
October 1994,
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S Hirai, and
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January 2009,
Lung,
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September 2000,
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January 1996,
Clinical and experimental immunology,
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February 2005,
Coronary artery disease,
S Hirai, and
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April 2023,
Life (Basel, Switzerland),
S Hirai, and
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K Imai, and
T Ono
October 1997,
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July 1998,
British journal of cancer,
S Hirai, and
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January 1997,
British journal of cancer,
S Hirai, and
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K Imai, and
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November 2010,
Chest,
