-transparent.png){kind=logo}
Although peroxisomes are ubiquitous, differences in the number of organelles and in the expression of associated metabolic activities are observed, depending on the cell type. To investigate the control of peroxisomal activity in connection with cell differentiation, we constructed hybrids between two types of cells whose histogenetic origins dictate significant differences in peroxisomal activities: hepatoma cells and fibroblasts, with high and low expression, respectively, of peroxisomal functions. In these hybrids, extinction of the elevated activities that characterize liver cells is observed, in parallel with the well-documented extinction of differentiated functions. This suggests the existence in fibroblasts of a negative trans-acting regulation.
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
January 1975,
Somatic cell genetics,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
January 1971,
Proceedings of the National Academy of Sciences of the United States of America,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
September 1984,
Somatic cell and molecular genetics,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
May 1982,
Somatic cell genetics,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
March 1972,
Proceedings of the National Academy of Sciences of the United States of America,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
June 1976,
Differentiation; research in biological diversity,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
January 1991,
Somatic cell and molecular genetics,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
January 1972,
Biochimie,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
July 1975,
Somatic cell genetics,
E B Bioukar, and
S Sarrazin, and
M Conti, and
E Rabetafika, and
J P Carreau, and
S Dhorne-Pollet, and
N Raynaud, and
J Deschatrette
April 1972,
Journal of cellular physiology,
