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The non-obese diabetic (NOD) mouse displays several immune related defects, each of which could potentially contribute to the immunopathogenesis of diabetes that spontaneously develops in these mice. The reported resistance of NOD-lymphocytes to several apoptosis-inducing signals constitutes one such factor. Apoptosis plays a key role in the homeostasis of the immune system, as a means of selecting lymphocyte repertoires both in primary lymphoid organs and in the periphery; distortions in the apoptotic machinery may therefore be hypothesized to be implicated in the pathogenesis of autoimmune disorders. We now report that cyclophosphamide constitutes an apoptosis signal to peripheral lymphocytes and we provide evidence that NOD B cells as well as both CD4 and CD8 T cells display resistance to cyclophosphamide-induced apoptosis. These observations support the notion that apoptosis resistance in NOD mice exists at various levels, and suggest that the CY-sensitive lymphoid population, believed to play an important role in inhibiting the disease in diabetes resistant NOD mice (particularly males), may be controlled by mechanisms that are mediated by apoptosis.
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
January 1992,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
August 1994,
AIDS research and human retroviruses,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
January 1997,
Journal of clinical immunology,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
February 1991,
FEBS letters,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
February 2001,
Trends in microbiology,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
July 1993,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
December 2003,
Arhiv za higijenu rada i toksikologiju,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
January 1996,
Wiener klinische Wochenschrift,
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
July 1998,
Archives of surgery (Chicago, Ill. : 1960),
F Colucci, and
C M Cilio, and
K Lejon, and
C P Gonçalves, and
M L Bergman, and
D Holmberg
October 1999,
Ugeskrift for laeger,
