-transparent.png){kind=logo}
Effects of capsaicin, an essential ingredient of hot peppers, on high voltage-activated (HVA) calcium channels were investigated in voltage-clamped and internally perfused acutely dissociated rat trigeminal and hippocampal neurones. In micromolar concentrations capsaicin inhibited the whole HVA Ca2+ current without affecting resting membrane conductance in both types of neurones. IC50 values of 14.5 microM and 21.2 microM (n = 5) were obtained in sensory and hippocampal neurones, respectively. Capsaicin-induced inhibition became irreversible after prolonged incubation (30 s) with the drug. It is concluded that capsaicin is a nonspecific blocker of HVA Ca2+ channels in different types of nerve cells.
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
April 1994,
European journal of pharmacology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
August 1990,
British journal of pharmacology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
December 1998,
Pflugers Archiv : European journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
July 1998,
The Journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
August 1997,
The Journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
December 1999,
The Journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
August 2000,
The Journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
March 2009,
Journal of neuroendocrinology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
March 1996,
The Journal of physiology,
M V Kopanitsa, and
V A Panchenko, and
E I Magura, and
P V Lishko, and
O A Krishtal
February 1991,
The Journal of physiology,
