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Newly defined lipophilic indexes, log k', of a series of penicillins and cephalosporins were rapidly and reliably determined by reversed-phase high-pressure liquid chromatography (HPLC) on bonded octadecylsilane supports. The log k' values obtained from their retention times exhibited a linear relationship with methanol concentration (v/v%) in the mobile phase. The extrapolated log k' values to zero and those at 30% correlated well with the partition coefficients, log P, in 1-octanol-water and with Rm values from TLC. This HPLC technique provided some new log P and Rm values for highly ionizable beta-lactam antibiotics. The HPLC method for the determination of partition coefficients of drugs has some advantages and is a useful alternative for the determination of log P and Rm.
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