Biomaterial Database

Cytogenetic effect of some anti-tuberculosis drugs in vitro. 1977

I C Roman, and L Georgian

The comparative cytogenetic effects of some widely used anti-tuberculosis drugs (PAS Na, PRA, RMA) were estimated depending on the in vitro administered concentrations, in human peripheral blood cultures. The structural chromosomal lesions were randomly distributed between the different chromosome groups of the human karyotype; nearly 10 to 30% of affected cells had more than one lesion per metaphase. In the treatements with PAS Na and PRA the analysis of the frequencies of the cell carring chromosomal aberrations and of the chromosomal lesion types indicated a dose-response correlation. The significance of the results obtained in vitro on the chromosome-breaking effects of anti-tuberculosis agents and the genetic peril is pointed out.

UI	MeSH Term	Description	Entries
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D010131	Aminosalicylic Acid	An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.	4-Aminosalicylic Acid,p-Aminosalicylic Acid,para-Aminosalicylic Acid,Alumino-4-Aminosalicylic Acid,Pamisyl,Rezipas,p-Aminosalicylic Acid Monolithium Salt,p-Aminosalicylic Acid Monopotassium Salt,p-Aminosalicylic Acid Monosodium Salt,p-Aminosalicylic Acid, Aluminum (2:1) Salt,p-Aminosalicylic Acid, Calcium (2:1) Salt,p-Aminosalicylic Acid, Monosodium Salt, Dihydrate,4 Aminosalicylic Acid,Acid, Aminosalicylic,Alumino 4 Aminosalicylic Acid,p Aminosalicylic Acid,p Aminosalicylic Acid Monolithium Salt,p Aminosalicylic Acid Monopotassium Salt,p Aminosalicylic Acid Monosodium Salt,para Aminosalicylic Acid
D011718	Pyrazinamide	A pyrazine that is used therapeutically as an antitubercular agent.	Tisamid
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D002842	Chromatids	Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Chromatid
D002869	Chromosome Aberrations	Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.	Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002875	Chromosomes	In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Chromosome
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000995	Antitubercular Agents	Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.	Anti-Tuberculosis Agent,Anti-Tuberculosis Agents,Anti-Tuberculosis Drug,Anti-Tuberculosis Drugs,Antitubercular Agent,Antitubercular Drug,Tuberculostatic Agent,Tuberculostatic Agents,Antitubercular Drugs,Agent, Anti-Tuberculosis,Agent, Antitubercular,Agent, Tuberculostatic,Anti Tuberculosis Agent,Anti Tuberculosis Agents,Anti Tuberculosis Drug,Anti Tuberculosis Drugs,Drug, Anti-Tuberculosis,Drug, Antitubercular