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The effect of the nutrient medium acidity on the growth of the carminomycin-producing organism and formation of the carminomycin complex with its aid was studied. Satisfactory development of the organism was observed when pH of the nutrient medium on the culture inoculation was 4.9 to 8.5. A shift in the alkaline and acid values of pH to 6.3--6.4 was registered during the first 24 hours of the culture growth. The biosynthesis of carminomycin depended on the culture growth time and pH value of the nutrient medium and culture fluid during the fermentation process. Maximum production of the carminomycin complex and its active components was observed on the 7th--8th day of the culture growth. The medium reaction close to the neutral one was optimal for biosynthesis of the carminomycin complex and its active components. Under acid, as well as alkaline conditions the antibiotic production was markedly lower.
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
June 1981,
Antibiotiki,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
June 1976,
Antibiotiki,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
February 1976,
Antibiotiki,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
May 1975,
Antibiotiki,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
January 1982,
Voprosy onkologii,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
January 1957,
Schweizerische Zeitschrift fur Pathologie und Bakteriologie. Revue suisse de pathologie et de bacteriologie,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
October 1986,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
August 1975,
Archives of oral biology,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
January 1973,
Mikrobiologiia,
G V Kochetkova, and
E G Gladkikh, and
V I Ponomarenko
January 1978,
Antibiotiki,
