Biomaterial Database

Drosophila melanogaster genomic DNA sequence homologous to mammalian cytosine DNA-methyltransferase gene. 1996

B F Vanyushin, and L A Poirier

Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.

Using Southern blotting procedure we have shown that Drosophila genomic DNA hybridizes with 4423-bp C-terminal fragment of murine cytosine DNA-methyltransferase gene. Thus, the Drosophila genome has a sequence homologous to the mammalian cytosine DNA-methyltransferase gene. We assume that DNA methylation most likely responsible for strong CpG suppression in the Drosophila genome mainly was catalyzed by a cytosine DNA-methyltransferase that has since been lost.

UI	MeSH Term	Description	Entries
D008322	Mammals	Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.	Mammalia,Mammal
D004331	Drosophila melanogaster	A species of fruit fly frequently used in genetics because of the large size of its chromosomes.	D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012689	Sequence Homology, Nucleic Acid	The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.	Base Sequence Homology,Homologous Sequences, Nucleic Acid,Homologs, Nucleic Acid Sequence,Homology, Base Sequence,Homology, Nucleic Acid Sequence,Nucleic Acid Sequence Homologs,Nucleic Acid Sequence Homology,Sequence Homology, Base,Base Sequence Homologies,Homologies, Base Sequence,Sequence Homologies, Base
D015257	DNA-Cytosine Methylases	Methylases that are specific for CYTOSINE residues found on DNA.	Cytosine-Specific DNA Methylase,DNA Modification Methylases (Cytosine-Specific),DNA-Cytosine Methylase,Modification Methylases (Cytosine-Specific),Site-Specific DNA Methyltransferase (Cytosine-Specific),Site-Specific Methyltransferases (Cytosine-Specific),Cytosine-Specific DNA Methylases,DNA Modification Methylases Cytosine Specific,Modification Methylases (Cytosine Specific),Site Specific Methyltransferases (Cytosine Specific),Cytosine Specific DNA Methylase,Cytosine Specific DNA Methylases,DNA Cytosine Methylase,DNA Cytosine Methylases,DNA Methylase, Cytosine-Specific,DNA Methylases, Cytosine-Specific,Methylase, Cytosine-Specific DNA,Methylase, DNA-Cytosine,Methylases, Cytosine-Specific DNA
D016678	Genome	The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.	Genomes
D017422	Sequence Analysis, DNA	A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.	DNA Sequence Analysis,Sequence Determination, DNA,Analysis, DNA Sequence,DNA Sequence Determination,DNA Sequence Determinations,DNA Sequencing,Determination, DNA Sequence,Determinations, DNA Sequence,Sequence Determinations, DNA,Analyses, DNA Sequence,DNA Sequence Analyses,Sequence Analyses, DNA,Sequencing, DNA