Biomaterial Database

Bioenergetic effects of repeated +Gz acceleration on rat heart: a 31P-NMR study on isolated hearts. 1996

C C Tran, and J Aussedat, and A Ray, and S Lortet, and A Rossi, and P Quandieu

Institut de Médecine Aérospatiale du Service de Santé des Armées, Brétigny-sur-Orge, France.

This investigation was designed to determine whether repeated exposure to high sustained +Gz acceleration induces persisting changes in the myocardial energetic metabolism. Rats were exposed to three plateaus of 30 s at 10 +Gz, four times a week, for 4 weeks. Myocardial concentrations of high-energy phosphorylated compounds were evaluated by 31P-nuclear magnetic resonance (NMR) spectroscopy on isolated hearts submitted to isovolumic aortic perfusion. Heart performances were recorded using the intraventricular balloon method. Compared to the hearts of control rats (n = 5), the hearts of centrifuged rats (n = 5) had higher concentrations of inorganic phosphate (Pi:1.40 +/- 0.33 nM vs. 0.36 +/- 0.07 mM; p < 0.01), decreased phosphocreatine concentrations (PC:15 +/- 0.39 mM vs. 15.69 +/- 0.19 mM; p < 0.01), and a lower left ventricular developed pressure (LVDP) (21 +/- 1 mmHg vs. 34 +/- 2 mmHg; p < 0.01). The workload was increased by sequential augmentation of calcium in the perfusion medium. The relationship between LVDP and the Pi/PC ratio showed that the cost of the cardiac work was greater for the centrifuged rats.

UI	MeSH Term	Description	Entries
D008279	Magnetic Resonance Imaging	Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.	Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D010759	Phosphorus Isotopes	Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope.	Isotopes, Phosphorus
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260	Female		Females
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D017725	Ventricular Pressure	The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.	Intraventricular Pressure,Intraventricular Pressures,Pressure, Intraventricular,Pressure, Ventricular,Pressures, Intraventricular,Pressures, Ventricular,Ventricular Pressures
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus