BIOMAT Database Logo BIOMAT Database Logo

CD69 expression on primitive progenitor cells and hematopoietic malignancies. 1996

P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Department of Experimental and Clinical Medicine, Facoltà di Medicina e Chirurgia, Catanzaro, Italy.

CD69 is an early activation antigen of peripheral blood lymphocytes and is constitutively expressed on a wide variety of bone marrow-derived cells. To further characterize the distribution and understand the potential biological role of the molecule in normal and malignant hematopoiesis, we used a novel high affinity anti-CD69 mAb (UN6) and analyzed hematopoietic progenitor cells together with a panel of myeloid and lymphoid malignancies. We report that mobilized peripheral blood CD34+ cells display detectable levels of CD69 and that the density of membrane expression correlates with the immature phenotype CD34bright Thy-1bright cells. Furthermore, during cytokine-induced differentiation, the expression of CD69 is moderately down-regulated. Analysis of hematopoietic malignancies revealed that CD69 expression correlates with the immature myeloid phenotype. Taken together these data suggest a role of CD69 during the early phase of hematopoiesis and in the leukemic transformation.

UI MeSH Term Description Entries
D007938 Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) Leucocythaemia,Leucocythemia,Leucocythaemias,Leucocythemias,Leukemias
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005434 Flow Cytometry Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake. Cytofluorometry, Flow,Cytometry, Flow,Flow Microfluorimetry,Fluorescence-Activated Cell Sorting,Microfluorometry, Flow,Cell Sorting, Fluorescence-Activated,Cell Sortings, Fluorescence-Activated,Cytofluorometries, Flow,Cytometries, Flow,Flow Cytofluorometries,Flow Cytofluorometry,Flow Cytometries,Flow Microfluorometries,Flow Microfluorometry,Fluorescence Activated Cell Sorting,Fluorescence-Activated Cell Sortings,Microfluorimetry, Flow,Microfluorometries, Flow,Sorting, Fluorescence-Activated Cell,Sortings, Fluorescence-Activated Cell
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000945 Antigens, Differentiation, T-Lymphocyte Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function. Antigens, Differentiation, T-Cell,Differentiation Antigens, T-Cell,L3T4 Antigens,Leu Antigens, T-Lymphocyte,T-Cell Differentiation Antigens,T-Lymphocyte Differentiation Antigens,T6 Antigens,Antigens, Differentiation, T Lymphocyte,Differentiation Antigens, T Lymphocyte,Antigens, L3T4,Antigens, T-Cell Differentiation,Antigens, T-Lymphocyte Differentiation,Antigens, T-Lymphocyte Leu,Antigens, T6,Differentiation Antigens, T Cell,Differentiation Antigens, T-Lymphocyte,Leu Antigens, T Lymphocyte,T Cell Differentiation Antigens,T Lymphocyte Differentiation Antigens,T-Lymphocyte Leu Antigens
D015214 Antigens, Differentiation, Myelomonocytic Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas. Differentiation Antigens, Myelomonocytic,Myelomonocytic Differentiation Antigens,Antigens, Myelomonocytic, Differentiation,Antigens, Myelomonocytic Differentiation

Related Publications

P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Gene expression of cytokines suppressing hematopoietic progenitor cells in lymphoid malignancies.
January 1991, Journal of cancer research and clinical oncology,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Ex vivo expansion of primitive murine hematopoietic progenitor cells on porcine endothelial cells.
June 1997, Transplantation proceedings,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
CD84 expression on human hematopoietic progenitor cells.
September 2003, Experimental hematology,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Primitive hematopoietic progenitor cells are present in peripheral blood autografts.
January 1994, Blood cells,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Identification of primitive hematopoietic progenitor cells in the rhesus macaque.
February 2001, Journal of medical primatology,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Expression and function of integrins on hematopoietic progenitor cells.
January 1997, Acta haematologica,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Cytokine receptor expression on hematopoietic stem and progenitor cells.
January 1997, Blood,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
[Fas antigen expression on human hematopoietic progenitor cells].
July 1996, Nihon rinsho. Japanese journal of clinical medicine,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
CD105 (endoglin) expression on hematopoietic stem/progenitor cells.
January 2001, Leukemia & lymphoma,
P Tassone, and M C Turco, and F Tuccillo, and P Bonelli, and G Morrone, and L Cecco, and M Cerra, and H Bond, and M Di Nicola, and A M Gianni, and S Venuta
Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells.
November 1997, Blood,
Copied contents to your clipboard!