BIOMAT Database Logo BIOMAT Database Logo

Toxic effects of acute inhalation exposure to 1,2,4-trimethylbenzene (pseudocumene) in experimental animals. 1995

Z Korsak, and R Swiercz, and K Rydzynski
Department of Toxicity Evaluation, The Nofer Institute of Occupational Medicine, Lodz, Poland.

Neurotoxic and sensory respiratory irritation effects of 1,2,4-trimethylbenzene (pseudocumene) in male rats and male Balb/C mice were investigated in condition of acute inhalation exposure. Rotarod performance and pain sensitivity behaviour were tested in rats exposed to pseudocumene at concentrations of 1230-9840 mg/m3 (250-2000 ppm) immediately after termination of a four-hour exposure. The respiratory rate was measured in mice by the whole body plethysmographic method in 6 min duration exposure to various concentrations of pseudocumene. Exposure to pseudocumene resulted in concentration-dependent disturbances in rotarod performance, decrease in pain sensitivity in rats and depression of respiratory rate in mice. The EC50 value for rotarod performance behaviour disturbances was 4693 mg/m3 (954 ppm) and for decrease pain sensitivity EC50 was 5682 mg/m3 (1155 ppm). The concentration depressing the respiratory rate to 50% (RD50) was 2843 mg/m3 (578 ppm). As based on RD50 value the MAC values for pseudocumene 85 mg/m3 (17.0 ppm) is suggested.

UI MeSH Term Description Entries
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D009420 Nervous System The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed) Nervous Systems,System, Nervous,Systems, Nervous
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D012137 Respiratory System The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about. Respiratory Tract,Respiratory Systems,Respiratory Tracts,System, Respiratory,Tract, Respiratory
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D001555 Benzene Derivatives Organic compounds derived from BENZENE. Derivatives, Benzene

Related Publications

Z Korsak, and R Swiercz, and K Rydzynski
Toxicokinetics and metabolism of pseudocumene (1,2,4-trimethylbenzene) after inhalation exposure in rats.
January 2002, International journal of occupational medicine and environmental health,
Z Korsak, and R Swiercz, and K Rydzynski
Behavioral changes following 4-week inhalation exposure to pseudocumene (1,2,4-trimethylbenzene) in the rat.
January 1997, Neurotoxicology and teratology,
Z Korsak, and R Swiercz, and K Rydzynski
Sub-chronic inhalation toxicity of 1,2,4-trimethylbenzene (pseudocumene) in rats.
January 2000, International journal of occupational medicine and environmental health,
Z Korsak, and R Swiercz, and K Rydzynski
Neurotoxic effects of acute and subchronic inhalation exposure to trimethylbenzene isomers (pseudocumene, mesitylene, hemimellitene) in rats.
January 1996, International journal of occupational medicine and environmental health,
Z Korsak, and R Swiercz, and K Rydzynski
[Effect of 1,2,4-trimethylbenzene inhalation on energy metabolism in experimental animals].
January 2002, Patologicheskaia fiziologiia i eksperimental'naia terapiia,
Z Korsak, and R Swiercz, and K Rydzynski
Inhalation toxicokinetics of 1,2,4-trimethylbenzene in volunteers: comparison between exposure to white spirit and 1,2,4-trimethylbenzene alone.
June 1997, The Science of the total environment,
Z Korsak, and R Swiercz, and K Rydzynski
Toxic effects of acute inhalation exposure to 1,2,4,5-tetramethylbenzene (durene) in experimental animals.
January 1998, International journal of occupational medicine and environmental health,
Z Korsak, and R Swiercz, and K Rydzynski
Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat.
February 1989, Xenobiotica; the fate of foreign compounds in biological systems,
Z Korsak, and R Swiercz, and K Rydzynski
Developmental toxicity of two trimethylbenzene isomers, mesitylene and pseudocumene, in rats following inhalation exposure.
July 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Z Korsak, and R Swiercz, and K Rydzynski
Toxic effects of acute inhalation exposure to 1-methylnaphthalene and 2-methylnaphthalene in experimental animals.
January 1998, International journal of occupational medicine and environmental health,
Copied contents to your clipboard!