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Erythropoietin stimulates the erythropoietin responsive cell to undergo DNA synthesis and subsequent mitosis. To define further the physiology of this effect, a liquid suspension microculture utilizing mouse fetal liver cells was developed. Tritiated thymidine incorporation into erythroid precursors was found to parallel radiolabeled iron incorporation with peak DNA synthesis occurring after 24 hours of culture. Both tritiated thymidine and iron incorporation were dependent on erythropoietin concentration. The responsiveness to erythropoietin decreased when erythropoietin was withheld and this diminishment in reactivity paralleled a morphological differentiation of the cells. This observation, together with the finding that erythropoietin activity could be removed by absorption with large numbers of cells, suggests the proliferation induced by erythropoietin depends on a specific stage in the differentiation of the red blood cell and may be mediated through a specific cellular receptor.
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
January 1963,
The Journal of laboratory and clinical medicine,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
May 1967,
Experientia,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
December 1983,
Journal of immunological methods,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
September 1993,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
July 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
January 1967,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
January 1971,
Voprosy neirokhirurgii,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
January 1965,
Minerva radiologica,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
June 1979,
Journal of the National Cancer Institute,
T N Fredrickson, and
K A Smith, and
C J Cornell, and
C Jasmin, and
O R McIntyre
January 1966,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
