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Agelasphin-11 (AGL-11), a novel alpha-galactosylceramide isolated from an extract of a marine sponge, Agelas mauritianus, markedly prolonged the life span of mice intraperitoneally inoculated with B16 cells. Since AGL-11 did not show any direct cytotoxic activity against B16 cells, this compound is considered to be a biological response modifier (BRM). We focused on the enhancing effect of this compound on in vivo natural killer (NK) cell activity because several BRMs have already been determined to enhance the in vivo natural killer (NK) cell activity. When we evaluated the enhancing activity of AGL-11 using normal mice, AGL-11 enhanced in vivo NK cell activity more potently than Poly I:C, which is a positive control. In addition, we examined the effect of this compound on the NK cell activity of tumor-bearing mice, and found that AGL-11 recovers the reduced NK cell activity in a tumor-bearing condition to a higher level than that of normal mice. These results suggest that AGL-11 shows antitumor activity by the activation of antitumor effector cells such as NK cells.
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
January 1988,
Cancer immunology, immunotherapy : CII,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
January 2013,
In vivo (Athens, Greece),
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
June 1983,
[Osaka Daigaku shigaku zasshi] The journal of Osaka University Dental Society,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
January 1985,
Immunology letters,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
March 2000,
Proceedings of the National Academy of Sciences of the United States of America,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
July 1983,
Clinical immunology and immunopathology,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
January 1983,
Nihon geka hokan. Archiv fur japanische Chirurgie,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
September 2012,
The journals of gerontology. Series A, Biological sciences and medical sciences,
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
June 1950,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E Kobayashi, and
K Motoki, and
T Natori, and
T Uchida, and
H Fukushima, and
Y Koezuka
January 1987,
Cancer immunology, immunotherapy : CII,
