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The effects of chewing gum, containing 0 and 4 mg nicotine, on F waves were studied in healthy volunteers in a repeated measure design. F responses were recorded from the abductor pollicis brevis muscle following stimulation of the median nerve at the wrist. The persistence and various amplitude measures were analysed. Chewing a 4 mg nicotine gum, with a considerable rise in systemic nicotine (6.4-37.4 ng/ml), failed to produce significant effects on F wave parameters in relation to the placebo baseline. The analysis of different F wave amplitude ranges, however, revealed significant nicotine-induced changes: a dose-related decrease of F responses > or = 500 microV and an increase of F waves between 200-290 microV. This may be due to an activation of Renshaw cells in the spinal cord.
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
January 1990,
Psychopharmacology,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
October 1982,
European journal of clinical pharmacology,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
March 2009,
Addictive behaviors,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
January 1989,
NIDA research monograph,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
June 1996,
Clinical pharmacology and therapeutics,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
April 2004,
Psychopharmacology,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
April 1984,
Clinical pharmacology and therapeutics,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
January 1991,
Journal of substance abuse,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
October 2018,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
H Strenge, and
G Schmidt, and
U Niederberger, and
H Porschke, and
H W Schütz
April 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
