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Since 1975, many cases of 5-fluorouracil (5-FU) associated cardiotoxicity have been described in the literature. A histopathological study of 5-FU induced cardiotoxicity was performed on 50 Swiss albino rats. Multiple interstitial myocardial hemorrhages, multifocal myofibre necroses, inflammatory reaction, vascular changes, valvulitis and pericarditis have been noted especially in the left heart ventricles of rats under study. The mechanism of 5-FU associated cardiotoxicity is controversial. A probable mechanism has been proposed; it explains the endothelial damage leading to extravasation of the drug containing blood into myocardium resulting in myofibre necroses and inflammatory reaction.
S Kumar, and
R K Gupta, and
N Samal
January 2022,
Oxidative medicine and cellular longevity,
S Kumar, and
R K Gupta, and
N Samal
January 2002,
Indian heart journal,
S Kumar, and
R K Gupta, and
N Samal
July 2022,
Archiv der Pharmazie,
S Kumar, and
R K Gupta, and
N Samal
January 1990,
European journal of gynaecological oncology,
S Kumar, and
R K Gupta, and
N Samal
January 1995,
The New Zealand medical journal,
S Kumar, and
R K Gupta, and
N Samal
January 1998,
Neoplasma,
S Kumar, and
R K Gupta, and
N Samal
January 2010,
Ugeskrift for laeger,
S Kumar, and
R K Gupta, and
N Samal
April 1980,
Tumori,
S Kumar, and
R K Gupta, and
N Samal
January 2012,
Cardiology journal,
