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Hepatic arterial infusion chemotherapy (HAIC) using implantable reservoir was performed for liver metastases of gastric cancer and the therapeutic effects were evaluated. A catheter was placed in the hepatic artery via left subclavian artery or by direct insertion at laparotomy. Cisplatin, adriamycin and 5-FU were administered. The liver metastases of gastric cancer without unresectable primary tumors and hepatectomy were divided into two groups, 16 HAIC cases (11 synchronous, 5 metachronous metastases) and 23 systemic chemotherapeutic cases (10 synchronous, 13 metachronous metastases). As a result, HAIC revealed a 62.5% response rate. The 50% survival period was 395 days for HAIC, and it was significantly prolonged compared with 198 days for systemic chemotherapy (p < 0.01). But 4 among 10 cases responding to HAIC showed subsequent extrahepatic spread of the disease. Treatment of these extra-hepatic lesions is difficult.
T Uemura, and
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Gan to kagaku ryoho. Cancer & chemotherapy,
T Uemura, and
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M Soda
July 1998,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Uemura, and
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H Kawai, and
M Suga, and
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M Yamamoto, and
M Soda
July 1998,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Uemura, and
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H Kawai, and
M Suga, and
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J Otani, and
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M Yamamoto, and
M Soda
October 2001,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Uemura, and
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M Suga, and
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J Otani, and
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K Yoshizane, and
Y Morokoshi, and
M Yamamoto, and
M Soda
November 2002,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Uemura, and
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H Kawai, and
M Suga, and
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J Otani, and
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K Yoshizane, and
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M Yamamoto, and
M Soda
October 2003,
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K Yoshizane, and
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M Yamamoto, and
M Soda
January 1984,
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July 1984,
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