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Cell volume regulation is a ubiquitous cell regulatory mechanism based on meticulously controlled ion transport mechanisms. Keeping the absolute volume constant seems to be of the highest priority for most cells and is achieved at the expense of altered intracellular ion concentrations. We have been able to demonstrate that ICln, a chloride channel cloned from epithelial cells, is paramount for the ability of swollen cells to regulate their volume back to that under resting conditions. A unique feature of ICln is the distinct sensitivity of these channels for nucleotides and nucleoside analogues added to the extracellular fluid. In addition, cromolyn sodium and nedocromil sodium, drugs used by patients with asthma, are able to impede the function of these channels.
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
November 1999,
Experimental physiology,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
January 1999,
The Journal of general physiology,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
October 2001,
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
December 1996,
Genomics,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
May 2001,
The Journal of biological chemistry,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
November 2011,
The Journal of biological chemistry,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
December 2003,
Biochimica et biophysica acta,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
January 2006,
Acta physiologica (Oxford, England),
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
January 2007,
Placenta,
M Gschwentner, and
A Susanna, and
A Schmarda, and
A Laich, and
U O Nagl, and
H Ellemunter, and
P Deetjen, and
J Frick, and
M Paulmichl
October 2023,
Journal of biomolecular structure & dynamics,
