-transparent.png){kind=logo}
Structure--activity relationships in cephalosporins prepared from penicillins. 1. 7beta-Acylamino derivatives of 3-benzyl- and 3-(3-pyridylmethyl)ceph-3-em-4-carboxylic acids. 1977
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
tert-Butyl 7beta-aminoceph-3-em-4-carboxylates carrying either benzyl or 3-pyridylmethyl substituents at position 3 have been prepared by a multistep modification of the penicillin nucleus. Acylation of either amine, followed by deprotection, gave a range of new cephalosporins. The relationship between structure and antibacterial activity is discussed. D-Phenylglycine proved to be a preferred side chain in both series.
Related Publications
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
May 1983,
The Journal of antibiotics,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
June 1976,
Journal of medicinal chemistry,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
January 1974,
Journal of medicinal chemistry,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
January 1968,
Journal of medicinal chemistry,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
May 1989,
Journal of medicinal chemistry,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
November 1974,
Helvetica chimica acta,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
March 1972,
Helvetica chimica acta,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
April 1989,
Journal of medicinal chemistry,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
July 1987,
Chemical & pharmaceutical bulletin,
E G Brain, and
A J Eglington, and
J H Nayler, and
N F Osborne, and
M J Pearson, and
T C Smale, and
R Southgate, and
P Tolliday, and
M J Basker, and
R Sutherland
October 1981,
The Journal of antibiotics,
