-transparent.png){kind=logo}
The present study has investigated whether nitric oxide (NO) is involved in neurotransmission of rat vagal afferent neurons. The diethylamine-NO complex (diethylamine-NO, 10-100 microM) and S-nitroso-N-acetylpenicillamine (3-100 microM) both elicited a concentration-dependent depolarisation of the isolated rat nodose ganglion preparation. Pre-treatment with 1 H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 300 nM), 6-(phenylamino)-5,8-quinolinedione (LY83,583, 30 microM) and Methylene blue (100 microM) all caused a significant shift to the right in the concentration-response curve to diethylamine-NO. Incubation of rat nodose ganglion sections with a 35S-labeled antisense oligonucleotide to neuronal NO synthase resulted in visualisation of the mRNA encoding NO synthase over vagal afferent perikarya. The anatomical findings, therefore, suggest that a number of rat vagal afferent perikarya possess the ability to produce the enzyme required for the biosynthesis of NO. Collectively, these data suggest that NO may be functionally important as a neuromodulator of rat vagal afferent neurons.
A J Lawrence, and
E Krstew, and
B Jarrott
March 1995,
Neuroscience,
A J Lawrence, and
E Krstew, and
B Jarrott
March 1994,
Neuroreport,
A J Lawrence, and
E Krstew, and
B Jarrott
March 2005,
Regulatory peptides,
A J Lawrence, and
E Krstew, and
B Jarrott
November 1994,
The American journal of physiology,
A J Lawrence, and
E Krstew, and
B Jarrott
January 2000,
Life sciences,
A J Lawrence, and
E Krstew, and
B Jarrott
March 2005,
Journal of molecular histology,
A J Lawrence, and
E Krstew, and
B Jarrott
August 1994,
Brain research,
A J Lawrence, and
E Krstew, and
B Jarrott
January 1997,
Neuroscience letters,
A J Lawrence, and
E Krstew, and
B Jarrott
May 1999,
Neuroscience,
A J Lawrence, and
E Krstew, and
B Jarrott
October 1993,
Neuroscience letters,
