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Effects of vagotomy on nitric oxide synthase (NOS) protein and mRNA levels in the dorsal motor nucleus of vagus (DMV) and nucleus ambiguus (NA) of rats were examined by nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining, brain NOS (bNOS) immunostaining and in situ hybridization. NADPH-d staining and bNOS immunoreactivity increased in neurons of the ipsilateral DMV and NA 5, 10, and 20 days after vagotomy. These changes were not observed in unoperated or sham-operated rats. In situ hybridization showed that bNOS mRNA levels were also elevated in neurons of DMV and NA on the operated side. Our results suggest that transection of vagal efferents up-regulates bNOS and its mRNA expression in the DMV and NA.
L H Lin, and
A Sandra, and
S Boutelle, and
W T Talman
April 1994,
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L H Lin, and
A Sandra, and
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W T Talman
July 1992,
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L H Lin, and
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W T Talman
November 1996,
European journal of pharmacology,
L H Lin, and
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W T Talman
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L H Lin, and
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L H Lin, and
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L H Lin, and
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May 2002,
Annals of the New York Academy of Sciences,
L H Lin, and
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W T Talman
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L H Lin, and
A Sandra, and
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W T Talman
May 1996,
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L H Lin, and
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W T Talman
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