Biomaterial Database

[Function of keratinocyte growth factor in wound healing]. 1996

S Werner, and M Brauchle, and G Hübner, and S Frank, and H Smola

Max-Planck-Institut für Biochemie, Martinsried.

UI	MeSH Term	Description	Entries
D005346	Fibroblast Growth Factors	A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.	DNA Synthesis Factor,Fibroblast Growth Factor,Fibroblast Growth Regulatory Factor,Growth Factor, Fibroblast,Growth Factors, Fibroblast
D006133	Growth Substances	Signal molecules that are involved in the control of cell growth and differentiation.	Mitogens, Endogenous,Endogenous Mitogens
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings
D015870	Gene Expression	The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.	Expression, Gene,Expressions, Gene,Gene Expressions
D017468	Receptors, Fibroblast Growth Factor	Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.	FGF Receptor Complex,FGF Receptor Complexes,FGF Receptors,Fibroblast Growth Factor Receptors,Receptors, FGF,FGF Receptor,Fibroblast Growth Factor Receptor,Heparin-Binding Growth Factor Receptor,Heparin Binding Growth Factor Receptor,Receptor, FGF
D051497	Receptor, Fibroblast Growth Factor, Type 2	A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).	Fibroblast Growth Factor Receptor 2,BEK Fibroblast Growth Factor Receptor,BEK Fibroblast Growth Factor Receptor Kinase,BEK Protein Tyrosine Kinase,Bek Fgf Receptor Kinase,Bek-Related Fibroblast Growth Factor-Receptor-1,CD332 Antigen,FGFR2 Protein,FGFR2b,FGFR2c,Fibroblast Growth Factor Receptor 2b,Fibroblast Growth Factor Receptor 2c,Fibroblast Growth Factor Receptors 2,Fibroblast Growth Factor Receptors 2b,Receptor, Fibroblast Growth Factor 2b,Receptor, Fibroblast Growth Factor 2c,Antigen, CD332,Bek Related Fibroblast Growth Factor Receptor 1
D051523	Fibroblast Growth Factor 7	A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.	Keratinocyte Growth Factor,Palifermin