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Adverse reactions are seen relatively frequently after treatment of onchocerciasis patients with ivermectin. The chemokines RANTES and IL-8, which have both chemotactic and activation properties for eosinophils and neutrophils, respectively, may have a role in the pathogenesis of post-treatment reactions. Circulating levels of the chemokines and the cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 were measured in the plasma of 22 Onchocerca volvulus-infected subjects. Peaks of mean circulating levels of RANTES and TNF-alpha were seen at 6 h after ivermectin administration. Peripheral eosinophil counts declined at 36 h post-treatment and an early peak in RANTES levels was associated with a delay in peripheral eosinopenia. RANTES levels were negatively correlated with severity of rash (P < 0.001) and lymphoedema (P < 0.05), suggesting that high circulating levels of RANTES may inhibit eosinophil sequestration. No changes in circulating levels of IL-8 were seen. These findings suggest a possible role of circulating RANTES in modulating eosinophil sequestration in vivo.
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
November 1989,
Australian and New Zealand journal of ophthalmology,
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
November 1983,
Bulletin de la Societe de pathologie exotique et de ses filiales,
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
October 1994,
The Journal of infectious diseases,
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
May 1986,
Australian veterinary journal,
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
January 1990,
Acta Leidensia,
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
June 1992,
Parasitology today (Personal ed.),
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
April 1992,
Parasitology today (Personal ed.),
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
October 1984,
Lancet (London, England),
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
September 1984,
Lancet (London, England),
P J Cooper, and
R H Guderian, and
D Prakash, and
D G Remick, and
I Espinel, and
T B Nutman, and
D W Taylor, and
G E Griffin
November 1984,
Lancet (London, England),
