Biomaterial Database

Modulating wavelength discrimination in goldfish with ethambutol and stimulus intensity. 1996

T Sjoerdsma, and M Kamermans, and H Spekreijse

Graduate School Neurosciences Amsterdam, The Netherlands Ophthalmic Research Institute, Laboratory for Medical Physics, The Netherlands.

Wavelength discrimination in goldfish was measured behaviourally. Both acute application of ethambutol injected into the eye and chronic application by feeding the animals daily 25 mg ethambutol for 1 month had the same effect on wavelength discrimination in the range of 560-640 nm. This means that: (1) electrophysiological experiments, in which drug application is primarily acute, reflect the same disturbance as behavioural experiments, in which drug application is chronic; and that (2) the origin of the color vision defect must be retinal. Furthermore reduction in stimulus intensity by 2 log units caused, in control fish, a similar disturbance in wavelength discrimination as induced by ethambutol, whereas an increase of stimulus intensity by 2 log units abolished in ethambutol-fed fish the discrimination disturbance. These results indicate that ethambutol shifts the threshold for wavelength discrimination without changing the absolute sensitivity of the cone systems.

UI	MeSH Term	Description	Entries
D003118	Color Perception	Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.	Color Perceptions,Perception, Color,Perceptions, Color
D004192	Discrimination, Psychological	Differential response to different stimuli.	Discrimination, Psychology,Psychological Discrimination
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004977	Ethambutol	An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)	Dexambutol,EMB-Fatol,EMB-Hefa,Etambutol Llorente,Ethambutol Hydrochloride,Etibi,Miambutol,Myambutol,EMB Fatol,EMB Hefa,Hydrochloride, Ethambutol,Llorente, Etambutol
D006054	Goldfish	Common name for Carassius auratus, a type of carp (CARPS).	Carassius auratus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D013053	Spectrophotometry	The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.