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When phenobarbitone was added to the treatment regimen of epileptic patients who received phenytoin only, the serum levels of phenytoin increased significantly within 6 weeks. Eleven weeks after the introduction of phenobarbitone, phenytoin levels had returned to those existing before phenobarbitone therapy. In view of possible complex pharmacokinetic interactions which might occur when phenobarbitone is added to a regimen of phenytoin, or vice versa, frequent measurement of serum drug levels appears to be indicated for up to 10 weeks after effecting a change in treatment. During this period a constant change in serum levels could be expected, resulting either in toxicity or lack of efficacy.
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
November 1974,
The British journal of psychiatry : the journal of mental science,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
January 1977,
Scandinavian journal of social medicine,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
March 1979,
Obstetrics and gynecology,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
August 1976,
Acta neurologica Scandinavica,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
January 1976,
Lancet (London, England),
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
September 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
December 1978,
Scandinavian journal of clinical and laboratory investigation,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
April 1982,
British journal of clinical pharmacology,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
July 1957,
The Journal of mental science,
F O Müller, and
A K Aucamp, and
H K Hundt, and
J M Steyn, and
L R Olivier, and
W H Wessels
January 1986,
Indian journal of physiology and pharmacology,
