-transparent.png){kind=logo}
The interaction between cyclophosphamide (CPA) and phenobarbital (PB) was investigated in B6D2F1 mice, checking both the antileukemic and immunosuppressive activity together with the serum levels of CPA and its metabolites. A reduced cytotoxic activity of CPA has been observed when PB is given for 2 days before CPA and an interval of at least 6 hours elapses between the last treatment of PB and the administration of CPA. On the contrary, when PB is given simultaneously with CPA for 2 or 4 consecutive days, an increased antileukemic activity of CPA occurs. In the experimental condition where PB decreases the activity of CPA, serum levels of CPA, assayed by means of a new specific gas-chromatographic method, and of its NBP-alkylating metabolites, indicate that this effect may be explained on a pure pharmacokinetic basis. However, for the situation where an increased effect of CPA was observed under the influence of PB, pharmacokinetic data did not provide a clear explanation.
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
December 1972,
Cancer research,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
August 1976,
Cancer research,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
January 2011,
Tsitologiia,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
April 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
April 1971,
The Journal of pharmacology and experimental therapeutics,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
March 2019,
Drug metabolism and disposition: the biological fate of chemicals,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
November 1968,
Teratology,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
October 1976,
Xenobiotica; the fate of foreign compounds in biological systems,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
January 2020,
Drug metabolism and disposition: the biological fate of chemicals,
M G Donelli, and
A Vecchi, and
A Bossi, and
T Colombo, and
M Sironi, and
C Pantarotto, and
S Garattini, and
F Spreafico
March 1973,
The Journal of pharmacology and experimental therapeutics,
