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1. The pharmacokinetics of cyclophosphamide and its alkylating metabolites have been studied in rats whose liver microsomal enzymes had been induced by phenobarbital pre-treatment. 2. Serum levels of cyclophosphamide were determined using a new g.l.c. method. The half-life of cyclophosphamide in blood of rats pre-treated with phenobarbital was shorter than in control rats. This change is closely related to higher rates of production of p-nitrobenzylpyridine-positive alkylating metabolites of cyclophosphamide, which in turn is followed by their more rapid disappearance from the circulation. 3. Urinary excretion reflects this situation; lower amounts of cyclophosphamide and higher concentrations of its alkylating metabolites are present in the urine of phenobarbital-treated rats. 4. Perfusion of livers isolated from phenobarbital-pre-treated rats confirmed the results in vivo. With this preparation, too, disappearance of cyclophosphamide was more rapid and formation of its alkylating metabolites was accelerated after phenobarbital treatment.
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
August 1976,
Cancer research,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
April 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
October 1973,
Biochemical pharmacology,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
April 1984,
Biochemical and biophysical research communications,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
December 1976,
Archives of biochemistry and biophysics,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
March 1973,
The Journal of pharmacology and experimental therapeutics,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
June 1989,
Toxicology and applied pharmacology,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
January 1996,
Drug metabolism and drug interactions,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
March 1972,
The Journal of laboratory and clinical medicine,
M G Donelli, and
A Guaitani, and
I Bartosek, and
A Bossi, and
T Colombo, and
S Garattini
January 1974,
Naunyn-Schmiedeberg's archives of pharmacology,
