-transparent.png){kind=logo}
Genetic absence epilepsy rats from Strasbourg (GAERS) have non-convulsive generalized seizures associated with spike-wave (SW) discharges, which are due to a hyperexcitable state of the thalamo-cortico circuits involving the reticular thalamic nucleus (nRt). Investigation of the primary genetically-determined defect responsible for GAERS epilepsy revealed the following abnormalities: (1) increased effectiveness of AMPA receptors dependent glutamate-mediated transmission; (2) impairment of GABA-mediated transmission in the neocortex; (3) increased amplitude of the voltage-dependent low-threshold Ca2(+)-current (I(T)) in the nRt. The maturational profile of these abnormalities supports the conclusion that the abnormality in the I(T) current in the nRt is the primary genetically-determined defect, which may secondarily induce the other changes found in the neocortex and thalamus of GAERS.
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
January 1999,
Progress in brain research,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
May 1993,
Brain research,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
February 2020,
Epilepsia,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
December 2009,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
December 1976,
Electroencephalography and clinical neurophysiology,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
February 2016,
Neuroscience,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
January 2004,
Uspekhi fiziologicheskikh nauk,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
October 2009,
Epilepsy research,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
April 1998,
Electroencephalography and clinical neurophysiology,
G Avanzini, and
M de Curtis, and
S Franceschetti, and
G Sancini, and
R Spreafico
July 1984,
Experimental neurology,
