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The nafcillin concentration of simultaneous cerebrospinal fluid (CSF) and serum specimens from nine patients being treated with parenteral nafcillin for staphylococcal infection were measured. Marked variations in the ratio of CSF/serum nafcillin concentration were observed. However, the concentration of nafcillin in the CSF was greater than the minimum lethal concentration (MLC) for Staphylococcus aureus in eight of the nine patients. In five patients with CSF pleocytosis, the nafcillin concentration was three to 100 times the MLC. These results support the recommendation to use nafcillin in doses of at least 100 to 200 mg/kg body weight-day for treatment of meningitis caused by S. aureus.
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1990,
Chemotherapy,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1964,
Antimicrobial agents and chemotherapy,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1958,
Antibiotics annual,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1980,
Journal of neurosurgery,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
November 1971,
Applied microbiology,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1987,
Reviews of infectious diseases,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
January 1965,
Archives of dermatology,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
July 1965,
Annals of internal medicine,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
July 1994,
The Journal of infection,
J G Kane, and
R H Parker, and
G W Jordan, and
P D Hoeprich
September 1965,
Eye, ear, nose & throat monthly,
