BIOMAT Database Logo BIOMAT Database Logo

Interferon and tumor necrosis factor production by peripheral blood leukocytes of patients with infectious mononucleosis. 1996

T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Department of Virology and Immunology, Maria Curie-Skłodowska University, Lublin, Poland.

Blood samples from 29 patients with infectious mononucleosis (IM) in phases of acute disease and convalescence were obtained. Interferon alpha (IFN-alpha) and tumor necrosis factor alpha (TNF-alpha) activity was detected in sera of patients both in: acute and convalescence phase, however when IFN titers were higher in the acute than convalescence phase, TNF titers were the highest in convalescence. In the whole blood assay Newcastle disease virus (NDV), phytohemagglutinin (PHA) and concanavalin A (ConA) and lipopolysaccharide (LPS) were used as cytokine inducers. A significant decrease in IFN titer induced in vitro with NDV, PHA and ConA was observed in blood leukocytes of patients in the acute IM phase. In convalescence the ability of blood leukocyte of IM patients to produce IFN returned to normal, comparable with control. However, blood leukocytes of IM patients in the acute phase produced more TNF in response to LPS than in convalescence. The role of the observed overproduction of TNF in the course of IM similar to that in HIV infection should be elucidated.

UI MeSH Term Description Entries
D007244 Infectious Mononucleosis A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis. Glandular Fever,Mononucleosis, Infectious,Fever, Glandular
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297 Male Males
D009522 Newcastle disease virus The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food. Avian Paramyxovirus 1,Paramyxovirus 1, Avian
D010835 Phytohemagglutinins Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture. Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D003289 Convalescence The period of recovery following an illness. Convalescences

Related Publications

T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Tumor necrosis factor and interferon production by peripheral blood leukocytes of patients with alcoholic cirrhosis.
January 1996, Archivum immunologiae et therapiae experimentalis,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Tołpa Torf Preparation (TTP) induces interferon and tumor necrosis factor production in human peripheral blood leukocytes.
January 1993, Archivum immunologiae et therapiae experimentalis,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Interleukin-1 and tumor necrosis factor production by tumor-associated mononuclear leukocytes and peripheral mononuclear leukocytes in cancer patients.
November 1988, International journal of cancer,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys.
April 2001, Toxicological sciences : an official journal of the Society of Toxicology,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Interferon production by peripheral blood leukocytes of patients with acute myeloid leukemia.
January 1996, Archivum immunologiae et therapiae experimentalis,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
[Cytochemical reactions of peripheral blood leukocytes in infectious mononucleosis].
September 1975, Polski tygodnik lekarski (Warsaw, Poland : 1960),
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
[Cytophotometric studies of DNA contents in peripheral blood leukocytes in patients with infectious mononucleosis].
January 1976, Acta haematologica Polonica,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration.
January 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Production of tumor necrosis factor, interleukin 1, and interferon-gamma by peripheral blood mononuclear cells from patients with primary biliary cirrhosis.
July 1990, Clinical immunology and immunopathology,
T Kamińska, and M Kandefer-Szerszeń, and A Szuster-Ciesielska, and G Rzeszowska, and H Markowska, and R Modrzewska
Tumor necrosis factor alpha production by oral leukocytes: influence of tumor necrosis factor genotype.
April 1998, Journal of periodontology,
Copied contents to your clipboard!