-transparent.png){kind=logo}
The Vilsmeier and the Arndt-Eistert reactions have been employed for the synthesis of 1-phenyl-2-chloroindole-3-acetic acid (4). The antiinflammatory activity of 2-chloroindole-3-carboxylic acid (1), 1- methyl-2-chloroindole-3-carboxylic acid (2), 1-phenyl-2-chloroindole-3-carboxylic acid (3), and 4 was compared with the activity of indomethacin in the carrageenin rat edema. The best results are given by compounds 1 and 2 bearing H or CH3 at position 1 and COOH at position 3.
Related Publications
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
February 1983,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
March 1970,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
October 1974,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
January 1981,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
May 1995,
Farmaco (Societa chimica italiana : 1989),
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
March 1977,
Arthritis and rheumatism,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
January 1999,
Drugs of today (Barcelona, Spain : 1998),
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
December 1977,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
September 1979,
Journal of medicinal chemistry,
A Andreani, and
D Bonazzi, and
M Rambaldi, and
A Guarnieri, and
F Andreani, and
P Strocchi, and
N Montanaro
January 1991,
Orthopedic nursing,
