-transparent.png){kind=logo}
The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.
Related Publications
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
April 1982,
Journal of medicinal chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
October 1977,
Journal of medicinal chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
October 1995,
Archiv der Pharmazie,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
July 1985,
Die Pharmazie,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
October 1993,
Journal of medicinal chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
September 1984,
Journal of medicinal chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
January 2008,
Arzneimittel-Forschung,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
March 1970,
Journal of medicinal chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
July 1977,
The Journal of organic chemistry,
W J Welstead, and
H W Moran, and
H F Stauffer, and
L B Turnbull, and
L F Sancilio
November 1983,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
