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22 outpatients with primary hyperlipoproteinemia type IIb and IV were treated in periods of eight weeks as follows: placebo; 0,15 g phenformin/day; 0,15 g phenformin + 1,5 g clofibrate/day; 1,5 g clofibrate/day; placebo. Compared to the first placeboperiode the serumtriglycerides were significantly lowered by phenformin (about 26%), by the combined treatment with phenformin + clofibrate (60%) and by clofibrate (51%) after eight weeks of treatment. The serumcholesterol was significantly lowered by phenformin (10%) and by the combined treatment with phenformin and clofibrate (14%), but not significantly by clofibrate (8%). After eight weeks of treatment with phenformin alone or in combination with clofibrate the body weight decreased significantly (1,9% or 1,4%). These changes in body weight were not related to changes in blood lipids. In conclusion, the combined treatment with 0,15 g clofibrate/day was more effective in lowering increased serum lipids than the treatment with phenformin or clofibrate alone.
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
May 1977,
MMW, Munchener medizinische Wochenschrift,
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
March 1974,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
February 1978,
Medizinische Klinik,
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
November 1973,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
December 1973,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
December 1976,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
June 1981,
Metabolism: clinical and experimental,
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
December 1978,
Medizinische Klinik,
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
January 1980,
Arzneimittel-Forschung,
T Koschinsky, and
P Lenhard, and
F A Gries, and
K H Vogelberg, and
G Wolfram, and
P D Lang, and
J Vollmar
June 1978,
Medizinische Klinik,
