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The excretion of D-glucaric-acid during 24 hours in the urine, which is a measure for the activity of microsomal liver enzymes, was determined in 33 newborns. From 22 newborns with non-hemolytic unconjugated hyperbilirubinemia 11 were treated with 7.5 mg phenobarbital per kilogram bodyweight 5 days and afterwards the excretion of D-glucaric-acid was measured. In contrast to the untreated newborns there was a significant decrease of the bilirubin concentration in the serum and a concomitant increase of the D-glucaric acid excretion from 0,052 mumol/day/kg to 0,388 mumol/day/kg (mean values). A negative correlation (r = -0,51) could be calculated between the bilirubin concentration in the serum and the excretion of D-glucaric-acid after treatment with phenobarbital.
B Roth, and
G Heimann, and
E Gladtke
January 1981,
Journal of perinatal medicine,
B Roth, and
G Heimann, and
E Gladtke
May 1975,
Pediatric research,
B Roth, and
G Heimann, and
E Gladtke
April 1980,
Archivos de farmacologia y toxicologia,
B Roth, and
G Heimann, and
E Gladtke
December 1981,
Ceskoslovenska gynekologie,
B Roth, and
G Heimann, and
E Gladtke
April 1981,
Lancet (London, England),
B Roth, and
G Heimann, and
E Gladtke
January 1980,
International journal of clinical pharmacology, therapy, and toxicology,
B Roth, and
G Heimann, and
E Gladtke
December 1976,
Research communications in chemical pathology and pharmacology,
B Roth, and
G Heimann, and
E Gladtke
November 1976,
Acta paediatrica Scandinavica,
B Roth, and
G Heimann, and
E Gladtke
October 1978,
Clinical chemistry,
B Roth, and
G Heimann, and
E Gladtke
January 1977,
Polish journal of pharmacology and pharmacy,
