BIOMAT Database Logo BIOMAT Database Logo

Loss of heterozygosity at chromosome 7q in human breast cancer: association with clinical variables. 1997

A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Department of Pathology, University and National Hospital of Iceland, Reykjavik, Iceland.

In this study 238 human primary breast cancers were analysed with 9 polymorphic microsatellite markers specific to region 7q21-q35 on chromosome 7. LOH was observed at one or more marker in 82 cases or (34%). The deletions were evenly distributed throughout the region. Patients were divided into two groups according to whether LOH was observed in their tumours or not, and tested for association with overall survival, the clinicopathological features: steroid receptor content, tumour size, node status, DNA ploidy and S-phase fraction, and LOH at other chromosomal regions. An association was found between 7q LOH and high S-phase fraction. An association was found between LOH at 7q and LOH at 1p, 3p, 9p, 13q and 17q. These results suggest the location of a putative tumour suppressor gene at chromosome 7q21-q35 that, in combination with other deletions, might enhance tumour growth.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D002897 Chromosomes, Human, Pair 7 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 7
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016147 Genes, Tumor Suppressor Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. Antioncogenes,Cancer Suppressor Genes,Emerogenes,Genes, Cancer Suppressor,Genes, Growth Suppressor,Genes, Metastasis Suppressor,Growth Suppressor Genes,Metastasis Suppressor Genes,Tumor Suppressor Genes,Anti-Oncogenes,Genes, Onco-Suppressor,Oncogenes, Recessive,Tumor Suppressing Genes,Anti Oncogenes,Anti-Oncogene,Antioncogene,Cancer Suppressor Gene,Emerogene,Gene, Cancer Suppressor,Gene, Growth Suppressor,Gene, Metastasis Suppressor,Gene, Onco-Suppressor,Gene, Tumor Suppressing,Gene, Tumor Suppressor,Genes, Onco Suppressor,Genes, Tumor Suppressing,Growth Suppressor Gene,Metastasis Suppressor Gene,Onco-Suppressor Gene,Onco-Suppressor Genes,Oncogene, Recessive,Recessive Oncogene,Recessive Oncogenes,Suppressor Gene, Cancer,Suppressor Gene, Growth,Suppressor Gene, Metastasis,Suppressor Genes, Cancer,Suppressor Genes, Growth,Suppressor Genes, Metastasis,Tumor Suppressing Gene,Tumor Suppressor Gene

Related Publications

A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity, chromosome 7q, and breast cancer.
June 1992, Lancet (London, England),
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions.
December 1995, International journal of cancer,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.
January 1992, Lancet (London, England),
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at chromosome 1p in human breast cancer.
October 1996, International journal of oncology,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.
September 1995, British journal of cancer,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 1q in human breast cancer.
September 1989, Proceedings of the National Academy of Sciences of the United States of America,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on the X chromosome in human breast cancer.
August 1995, Genes, chromosomes & cancer,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.
March 1999, British journal of cancer,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity on chromosome 7q in in vitro-immortalized human oral keratinocyte cell lines.
August 2002, Archives of oral biology,
A K Kristjansson, and G Eiriksdottir, and G Ragnarsson, and A Sigurdsson, and J Gudmundsson, and R B Barkardottir, and J G Jonasson, and V Egilsson, and S Ingvarsson
Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype.
June 2002, Cancer genetics and cytogenetics,
Copied contents to your clipboard!