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Enhancement of the locomotor response to apomorphine in pertussis toxin-treated animals depends on the site of pertussis toxin injection into the ventral tegmental area. 1997
Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210, USA.
The locomotor stimulant response to either systemic or intra-accumbens amphetamine was enhanced 1-2 weeks after pre-treatment with pertussis toxin (PTX) into any of 3 different sites in the ventral tegmental area (VTA). An enhanced response to either systemic or intra-accumbens apomorphine occurred only after pre-treatment into the central VTA. Thus, enhanced sensitivity to drugs of either pre- or post-synaptic elements in the nucleus accumbens may develop depending on the site of the PTX pre-treatment within the VTA.
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