BIOMAT Database Logo BIOMAT Database Logo

Significance of urinary epidermal growth factor and its receptor expression in human bladder cancer. 1997

N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Department of Pathology, National Cheng Kung University, Tainan, Taiwan, Republic of China.

The expression of epidermal growth factor receptor (EGFR) has been suggested to play an important role in the progression of bladder cancer through paracrine stimulation by epidermal growth factor in the urine. However, there is no information regarding the expression of EGFR and urinary ligand measurement in corresponding tumors in patients with bladder cancer. METHODS Paired analysis of urinary levels of epidermal growth factor (U-EGF) and the expression of EGFR was performed on 48 cases of bladder cancer. U-EGF test and EGFR status were correlated with clinicopathologic factors of bladder cancer, and compared for their prognostic value with a mean follow-up of 39.7 months. RESULTS U-EGF was inversely correlated with the intensity of EGFR expression (p = 0.04); while no substantial relationship was observed with other conventional prognostic indicators (p > 0.1, respectively). Multivariate analysis revealed that factors correlated with the risk of recurrence were EGFR status (p = 0.03) and histological grading (p = 0.05). An important indicator associated with poor patient survival was size of tumor at diagnosis (p = 0.03). CONCLUSIONS Although measurement of U-EGF levels did not have any independent prognostic value, our data support the importance of urine EGF/urothelial EGFR interaction in the biological behavior of bladder cancer.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D004815 Epidermal Growth Factor A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. EGF,Epidermal Growth Factor-Urogastrone,Urogastrone,Human Urinary Gastric Inhibitor,beta-Urogastrone,Growth Factor, Epidermal,Growth Factor-Urogastrone, Epidermal,beta Urogastrone
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Epidermal growth factor receptor expression in urinary bladder cancer.
April 2011, Indian journal of urology : IJU : journal of the Urological Society of India,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Expression of epidermal growth factor receptor in urinary bladder cancer metastases.
April 1998, International journal of cancer,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer.
July 1999, Scandinavian journal of clinical and laboratory investigation,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Significance of human epidermal growth factor receptor 2 expression in colorectal cancer.
January 2015, Experimental and therapeutic medicine,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Significance of epidermal growth factor receptor expression in primary human endometrial cancer.
January 1994, International journal of cancer,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder.
June 2018, BMC urology,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer.
January 1997, Anticancer research,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Expression of human epidermal growth factor and its receptor in esophageal cancer.
May 1990, The Japanese journal of surgery,
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
Significance of epidermal growth factor receptor expression in breast cancer.
December 2011, Medical oncology (Northwood, London, England),
N H Chow, and H S Liu, and E I Lee, and C J Chang, and S H Chan, and H L Cheng, and T S Tzai, and J S Lin
[Expression of epidermal growth factor receptor and p53 protein in superficial cancer of the urinary bladder].
January 2001, Archivos espanoles de urologia,
Copied contents to your clipboard!