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Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumour in the urinary bladder using immunohistochemical techniques and a monoclonal antibody. Tumour material from 20 patients was investigated. The majority (13/20) of the metastases were homogeneously stained and showed a moderate to strong membranous staining for EGFR. The expression of EGFR in primary bladder tumours and metastases was similar. There was no indication that tumour tissue exposed to chemotherapy or radiation had a decreased number of EGFR. Targeting of the EGFR thus seems potentially applicable to metastatic disease.
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
April 2011,
Indian journal of urology : IJU : journal of the Urological Society of India,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
January 1997,
Anticancer research,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
January 2001,
Archivos espanoles de urologia,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
October 2002,
Postgraduate medical journal,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
July 1999,
Scandinavian journal of clinical and laboratory investigation,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
June 2018,
BMC urology,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
January 1995,
British journal of cancer,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
January 1992,
The Journal of urology,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
December 1990,
The British journal of surgery,
P Bue, and
K Wester, and
A Sjöström, and
A Holmberg, and
S Nilsson, and
J Carlsson, and
J E Westlin, and
C Busch, and
P U Malmström
November 2005,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
