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We previously demonstrated that cultured neonatal rat myocytes have the capacity to desaturate/elongate essential fatty acids, alpha-linolenic acid conversion being higher than linoleic acid conversion. The whole process of highly unsaturated fatty acid formation from linoleic and alpha-linolenic acids slows with aging. In this study we grew heart myocytes in culture for different periods of time, and we observed a decrease in the desaturating/elongating activities for both substrates as the cells aged in culture. Alpha-linolenic acid conversion into highly unsaturated fatty acids was less impaired by aging than linoleic acid conversion. These modifications are correlated to the age-dependent alterations observed in the total lipid fatty acid composition, which caused a decrease in the unsaturation index. Changes in the lipid composition that occur in aging cultures parallel those reported for several tissues upon aging in the whole animal. The data herein reported may suggest the possibility of counteracting the effects of aging on lipid metabolism by supplementing cultures with appropriate amounts of highly unsaturated fatty acids.
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
August 1988,
Mechanisms of ageing and development,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
January 1977,
Biochimie,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
December 1986,
Biochemistry,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
May 1986,
The American journal of physiology,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
January 1987,
Progress in clinical and biological research,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
January 1980,
Toxicology,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
February 1975,
The Journal of biological chemistry,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
October 1992,
Biochimica et biophysica acta,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
January 1975,
Biochemical Society transactions,
A Lorenzini, and
A Bordoni, and
C Spanò, and
E Turchetto, and
P L Biagi, and
S Hrelia
November 1995,
Biochemical and biophysical research communications,
